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KMID : 0357920010350020168
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Korean Journal of Pathology
2001 Volume.35 No. 2 p.168 ~ p.171
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Polyomavirus Renal Infection Confirmed by Electron Microscopy in a Patient with AcquiredImmunodeficiency Syndrome - An Autopsy Case Report -
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Kim Na-Rae
Kim Byoung-Kwon
Chi Je-Geun
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Abstract
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Polyomavirus infection commonly occurs in childhood and adolescence, remaining in a latent status and reactivated in an immunocompromised status. We report herein an autopsy case of HIV-positive 41-year-old male, who succumbed to disseminated Kaposi sarcoma and cytomegalovirus infection involving the gastrointestinal tract, lung and brain. The involved kidney showed minimal inflammatory infiltrates and tubular injury: the nuclei of tubular epithelial cells were markedly enlarged with central clearing and peripheral chromatin margination or bore basophilic nuclear inclusions. Inclusion-bearing tubular epithelial cells were negative for the viral immunostains including herpes simplex virus, Epstein-Barr virus and adenovirus. Electron microscopy disclosed 42 nm intranuclear viral particles compatible with the BK polyomavirus. The viral particles were icosahedral in paracrystalline array and nonenveloped.
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KEYWORD
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Polyomavirus, HIV, Kidney, Electron Microscopy
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